48 Hours “The Depraved Heart Murder” May 10 2025 Recap & Preview

This Saturday, May 10, 2025, at 9:00 PM ET/PT, 48 Hours presents an encore episode of “The Depraved Heart Murder”, reporting on the mysterious death of Sarah Harris and the investigation into her boyfriend, Dr. James Ryan, a prominent oral surgeon. Correspondent Nikki Battiste investigates this chilling case, where a young woman’s promising future was tragically cut short, and suspicions swirl around the person closest to her.

On January 26, 2022, Sarah Harris, a bright and ambitious woman from Maryland, was found unresponsive on the floor of the home she shared with Dr. Ryan. While Ryan claimed it was an accidental overdose, the discovery of toxic drugs in her system and mounting evidence uncovered by her family painted a different picture. Harris’ sister uncovered startling evidence that led police to question Ryan’s version of events, prompting a deeper investigation into their relationship and his involvement in her death.

Sarah’s family believed Ryan’s influence over her life went far beyond what he claimed, and they suspected he was responsible for introducing her to dangerous drugs. The investigation revealed that two powerful anesthetics, ketamine and propofol, were found in Sarah’s body—drugs Ryan had access to in his medical practice. As the case unfolded, Ryan was arrested and charged with depraved heart murder, a rare and severe charge for someone accused of causing death without direct intent, but through reckless disregard for human life.

The episode also explores the emotional toll on Sarah’s family and the questions that remain unanswered in this tragic case. Watch as 48 Hours uncovers the shocking details and the legal complexities of the investigation, which led to a charge of second-degree murder and other related charges.

Tune in Saturday, May 10, for “The Depraved Heart Murder” at 9:00 PM ET/PT on CBS, and streaming on Paramount+ for the full investigation into this haunting case.