ABC 20/20 “21 Days to Murder” September 19 2025

20/20 returns with an all-new, two-hour episode “21 Days to Murder”, airing Friday, September 19, 2025, at 9:01 p.m. EDT on ABC. The broadcast dives deep into the shocking story of Dr. James Craig, a Colorado dentist convicted of murdering his wife, Angela, by secretly lacing her protein shakes with poison.

Angela Craig’s sudden illness left doctors puzzled and her loved ones terrified. A devoted mother of six and a respected member of her Aurora community, she appeared to be living a fulfilling life alongside her successful husband. But when she died after a series of mysterious health episodes, investigators uncovered a far more disturbing picture.

Correspondent John Quiñones reports from Aurora, including inside access to Dr. Craig’s former dental practice — specifically Exam Room 9 — where key evidence was recovered. That evidence, tipped off by observant office staff, revealed a premeditated plot that unraveled a double life and a deadly betrayal.

The episode features exclusive interviews with those closest to the case. Dr. Karin Cain, a woman unknowingly entangled in Craig’s web of lies, shares her story publicly for the first time. She reveals how Craig deceived her into believing his marriage had ended while secretly planning his wife’s death. The program also includes never-before-seen bodycam footage, emotional interviews with Angela’s friends and family, and commentary from the law enforcement officials and medical experts who cracked the case.

With powerful storytelling and new revelations, “21 Days to Murder” uncovers the cold calculation behind a seemingly picture-perfect life, exposing how Craig’s secret relationships, financial pressures, and personal ambitions ended in tragedy.

Watch the full report on 20/20 Friday, September 19, on ABC. The episode will be available for streaming the next day on Hulu.